ABSTRACT
Introduction Severe acute respiratory illness (SARI) among pilgrims continues to be an important healthcare issue. The aim of the study is to describe the viral etiology of admitted patients during the 2022 peri-Hajj season in the Holly citifies of Makkah and Madinah. Methods This is a retrospective analysis of admitted patients with SARI and those patients were tested with multi-plex PCR for most common viral etiologies. Results A total of 179 cases of SARI were identified during the study period. Of the cases, 101 (56.4%) were males, 78 (43.6%) were females, and 78 (43.6%) were Saudi. The mean age (± SD) was 58.60 years (± 20.5) years. Those who were 65 years of age were the most common group (n=68;36%), followed by the age group 55-59 years (37 cases, 19%). The most frequent comorbidities were diabetes mellitus (n=67, 36%), hypertension (n=65, 35%), and chronic lung disease (34;18%). Of the included patients, 85 (47.5%) tested negative and 94 (42.5%) tested positive for various viral etiologies. The most frequently detected viruses were SARS-CoV-2 (n=28 cases;15%), influenza viruses (n=22 cases;12%) and influenza A (n=16) of which 43% were H3N2 and 6 cases for influenza B. The only MERS-CoV case was among a citizen and none of the visitors or residents had MERS-CoV. Of the total cases, 27 (14%) died during the follow up period. In a binary regression analysis, only age was associated with mortality (P=0.002). Conclusion The most frequently detected viruses among admitted patients with SARI were SARS-CoV-2 and influenza viruses. It is important to continue surveillance of admitted and non-admitted patients in different Hajj seasons to identify any shift in the etiologic agents.